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Paper II — 2014 September (Supplementary) (2010 Scheme) — Q9

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Paper II
2014 September (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Mechanism of action of metoclopramide

Q91 marksShort Answers

Answer

Metoclopramide is a dopamine D2 receptor antagonist (and 5-HT4 agonist at higher doses) that acts both centrally and peripherally: centrally, it blocks D2 receptors in the chemoreceptor trigger zone, producing an antiemetic effect; peripherally, it enhances acetylcholine release and increases gastric/upper GI motility (prokinetic effect) — increasing lower oesophageal sphincter tone, gastric emptying, and antroduodenal coordination.

  1. 1Antiemetics

Other Years Asked

  1. 1Enumerate Antiemetic drugs. Explain the Mechanism of action, uses and adverse effect of any one group. Briefly describe proton pump inhibitors (6+4+5)2024 June (Supplementary) (2019 Scheme)Essay · 15 marks
  2. 2List three classes of Antiemetics. Write the mechanism of action, uses and adverse effects of the most effective Antiemetic group. (3+5)2023 January (Supplementary) (2019 Scheme)Short Essay · 8 marks
  3. 3Enumerate Antiemetics. Add a brief note on mechanism of action, uses and adverse effects of the most effective group. (3+3)2025 March (Supplementary (SAY)) (2019 Scheme)Short Essay · 6 marks
  4. 4Metoclopramide2022 May (Supplementary) (2010 Scheme)Short Note · 3 marks
  5. 5Ondansetron2019 February (2010 Scheme)Short Note · 3 marks
  6. 6Aprepitant2018 February (2010 Scheme)Short Note · 3 marks
  7. 7Ondansetron2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  8. 8Metoclopramide2021 February (Supplementary) (2010 Scheme)Short Note · 3 marks
  9. 9Domperidone2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  10. 10Aprepitant2016 February (2010 Scheme)Short Answer · 1 mark
  11. 11Metoclopramide in vomiting.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  12. 12Cinnarizine2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  13. 13Metoclopramide2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  14. 145HT3 Antagonist (eg. ondansetron) is used in Chemotherapy induced vomiting2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  15. 155HT antagonists2013 April (2010 Scheme)Short Answer · 1 mark
  16. 16Antiemetic agents2015 February (2010 Scheme)Short Answer · 1 mark
  17. 17Vomiting2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  18. 18Metoclopramide.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  19. 19Motion sickness.2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  20. 20Domperidone in chemotherapy induced vomiting.2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  21. 21Antiemetics2021 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  22. 22Cetirizine for motion sickness Name the following (Two examples for each): (8x1=8)2022 February (2019 Scheme)Short Answer · 0.2 marks
  23. 23Prokinetic agents.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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