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Paper II — 2019 July (Supplementary) (2010 Scheme) — Q3

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Paper II
2019 July (Supplementary) (2010 Scheme)

Question

Domperidone

Q33 marksShort Notes

Answer

Domperidone is a dopamine D2 receptor antagonist with prokinetic and antiemetic properties.

Mechanism of action

  • Blocks D2 receptors in the chemoreceptor trigger zone (antiemetic effect) and peripherally in the GI tract (enhances gastric motility/emptying)
  • Does not readily cross the blood-brain barrier — minimal central/extrapyramidal side effects compared to metoclopramide

Uses

  • Nausea and vomiting
  • Gastroparesis, GERD (prokinetic)
  • Galactagogue (off-label, increases prolactin)

Adverse effects

  • Hyperprolactinaemia (galactorrhoea, gynaecomastia)
  • QT prolongation/cardiac arrhythmias (main safety concern — restricted use in many countries)
  • GI upset
  1. 1Antiemetics

Other Years Asked

  1. 1Enumerate Antiemetic drugs. Explain the Mechanism of action, uses and adverse effect of any one group. Briefly describe proton pump inhibitors (6+4+5)2024 June (Supplementary) (2019 Scheme)Essay · 15 marks
  2. 2List three classes of Antiemetics. Write the mechanism of action, uses and adverse effects of the most effective Antiemetic group. (3+5)2023 January (Supplementary) (2019 Scheme)Short Essay · 8 marks
  3. 3Enumerate Antiemetics. Add a brief note on mechanism of action, uses and adverse effects of the most effective group. (3+3)2025 March (Supplementary (SAY)) (2019 Scheme)Short Essay · 6 marks
  4. 4Metoclopramide2022 May (Supplementary) (2010 Scheme)Short Note · 3 marks
  5. 5Ondansetron2019 February (2010 Scheme)Short Note · 3 marks
  6. 6Aprepitant2018 February (2010 Scheme)Short Note · 3 marks
  7. 7Ondansetron2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  8. 8Metoclopramide2021 February (Supplementary) (2010 Scheme)Short Note · 3 marks
  9. 9Aprepitant2016 February (2010 Scheme)Short Answer · 1 mark
  10. 10Metoclopramide in vomiting.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  11. 11Cinnarizine2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  12. 12Metoclopramide2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  13. 135HT3 Antagonist (eg. ondansetron) is used in Chemotherapy induced vomiting2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  14. 145HT antagonists2013 April (2010 Scheme)Short Answer · 1 mark
  15. 15Antiemetic agents2015 February (2010 Scheme)Short Answer · 1 mark
  16. 16Mechanism of action of metoclopramide2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  17. 17Vomiting2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  18. 18Metoclopramide.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  19. 19Motion sickness.2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  20. 20Domperidone in chemotherapy induced vomiting.2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  21. 21Antiemetics2021 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  22. 22Cetirizine for motion sickness Name the following (Two examples for each): (8x1=8)2022 February (2019 Scheme)Short Answer · 0.2 marks
  23. 23Prokinetic agents.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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