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Paper II — 2024 December (Supplementary) (2019 Scheme) — Q11

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Paper II
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Classify insulins according to the duration of action giving suitable examples.

Q114 marksShort Answers

Answer

Classification of insulins by duration of action

CategoryExamplesOnsetDuration
Rapid-actingLispro, Aspart, Glulisine~10-15 min3-4 hours
Short-acting (regular)Regular (soluble) insulin~30 min6-8 hours
Intermediate-actingNPH (isophane)1-2 hours12-18 hours
Long-actingGlargine, Detemir1-2 hours18-24 hours
Ultra-long-actingDegludec~1 hourup to 42 hours

Rapid-acting analogs are used for prandial (meal-time) coverage, mimicking the physiological post-meal insulin spike, while long/ultra-long-acting agents provide a smooth, peakless basal level, together forming a basal-bolus regimen that more closely reproduces physiological insulin secretion than older regular/NPH combinations.

  1. 1Diabetes Mellitus and Oral Hypoglycaemic Drugs

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  5. 5(2024 June (Supplementary) (2019 Scheme)Short Essay · 8 marks
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  10. 10A 25years old insulin dependent diabetes mellitus patient develops sweating, anxiety, palpitations and tremors after performing vigorous exercise. Answer the following:2016 February (2010 Scheme)Essay · 6 marks
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  13. 13dl, HbA1c was 8%. A diagnosis of Type 2 diabetes was made….2024 March (Supplementary) (2010 Scheme)Essay · 6 marks
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