Question
Insulin analogs
Q6 3 marks Short Notes ★ ✓
Answer
Insulin analogs are recombinant insulin preparations with modified amino acid sequences that alter their absorption/action profile compared to human insulin.
Rapid-acting analogs (faster onset, shorter duration than regular insulin — used just before/with meals)
Insulin lispro
Insulin aspart
Insulin glulisine
Long-acting analogs (flat, peakless profile — basal insulin)
Insulin glargine
Insulin detemir
Insulin degludec
Advantages over conventional human insulin
Rapid-acting analogs: faster onset and shorter duration → better postprandial glucose control, less risk of late postprandial hypoglycaemia, can be given immediately before meals
Long-acting analogs: provide steady basal insulin levels without pronounced peaks → lower risk of nocturnal hypoglycaemia
1 Diabetes Mellitus and Oral Hypoglycaemic Drugs
Other Years Asked
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insulin (2+3+1=6) 2016 October (Supplementary) (2010 Scheme) Essay · 6 marks 9 Classify oral hypoglycemic agents. Explain the mechanism of action and adverse
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(2+2+1+1)2. A 30 years old male patient admitted to hospital with a complaint of fever with chills
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effects of sulfonylureas. (2+2+1+1) 2018 February (2010 Scheme) Essay · 6 marks 13 dl, HbA1c was 8%. A diagnosis of Type 2
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analogues over conventional insulin. How will you manage insulin resistance. (2+2+2) 2019 July (Supplementary) (2010 Scheme) Essay · 6 marks 15 dL, glycosylated
hemoglobin (HbA1 2025 August (Supplementary) (2010 Scheme) Essay · 6 marks 16 Enumerate insulin analogues and tabulate their pharmacokinetic characteristics. 2025 March (Supplementary (SAY)) (2019 Scheme) Short Answer · 4 marks 17 Classify insulins according to the duration of action giving suitable examples. 2024 December (Supplementary) (2019 Scheme) Short Answer · 4 marks 18 Metformin. 2022 July (Supplementary) (2019 Scheme) Short Answer · 4 marks 19 Alpha glucosidase inhibitors 2014 March (2010 Scheme) Short Note · 3 marks 20 Insulin analogues. 2013 September (Supplementary) (2010 Scheme) Short Note · 3 marks 21 Vildagliptin 2021 February (Supplementary) (2010 Scheme) Short Note · 3 marks 22 Dipeptidyl peptidase 4 (DPP-4) inhibitors 2021 December (Supplementary) (2010 Scheme) Short Note · 3 marks 23 Sulfonylureas in type II diabetes mellitus. 2017 February (2010 Scheme) Short Note · 3 marks 24 Short acting insulin analogues 2022 May (Supplementary) (2010 Scheme) Short Note · 3 marks 25 Newer Insulins 2023 July (Supplementary) (2010 Scheme) Short Note · 3 marks 26 Dipeptidyl Peptidase 4 inhibitors 2022 October (Supplementary) (2010 Scheme) Short Note · 3 marks 27 Metformin 2021 December (Supplementary) (2010 Scheme) Short Answer · 1 mark 28 Insulin used in diabetic ketoacidosis 2018 July (Supplementary) (2010 Scheme) Short Answer · 1 mark 29 Longest acting insulin given as once daily dose 2015 February (2010 Scheme) Short Answer · 1 mark 30 Insulin analogues 2017 August (Supplementary) (2010 Scheme) Short Answer · 1 mark 31 Peroxysome proliferator activated receptor gamma agonists 2015 February (2010 Scheme) Short Answer · 1 mark 32 Metformin 2023 July (Supplementary) (2010 Scheme) Short Answer · 1 mark 33 Metformin 2024 August (Supplementary) (2010 Scheme) Short Answer · 1 mark 34 Short acting insulin analogues 2024 March (Supplementary) (2010 Scheme) Short Answer · 0.3 marks 35 Short acting Insulin analogues 2025 August (Supplementary) (2010 Scheme) Short Answer · 0.3 marks 36 Long acting Insulin analogues 2024 August (Supplementary) (2010 Scheme) Short Answer · 0.3 marks 37 Lente insulin in diabetic ketoacidosis
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