Paper II
2023 July (Supplementary) (2010 Scheme)

Question

Domperidone/Metoclopramide as antiemetic in paediatric population Name the following (Two examples for each) (5x1=5)

Q150.3 marksShort Answers

Answer

Domperidone is the appropriate choice — unlike metoclopramide, it does not cross the blood-brain barrier appreciably, giving it the same D2-antagonist antiemetic benefit with substantially less central extrapyramidal risk. Metoclopramide crosses the BBB and carries a distinctly higher risk of dystonic reactions in children specifically, a well-recognized, mechanism-driven reason to prefer domperidone in the paediatric population.

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