Paper I
2024 August (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Glycopyrrolate/Atropine as a Pre anaesthetic medication Name the following (Two examples for each): (5x1=5)

Q150.3 marksShort Answers

Answer

Glycopyrrolate is the preferred choice — a quaternary ammonium compound that does not cross the blood-brain barrier (no central effects), with a longer duration of antisecretory action than atropine and less tachycardia. Atropine, a tertiary amine, crosses the BBB (risk of central anticholinergic effects) and has a shorter duration, making glycopyrrolate the more suitable pre-anesthetic antisialagogue in routine practice.

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