Paper I — 2013 April (2010 Scheme) — Q11

Paper I

2013 April (2010 Scheme) · 40 marks · 180 min

Question

Flumazenil

Q111 marksShort Answers★✓

Answer

Flumazenil is a competitive antagonist at the benzodiazepine binding site on the GABA-A receptor. It has no intrinsic activity of its own but blocks the actions of benzodiazepines by competitive antagonism.

• Use: Reversal of benzodiazepine-induced sedation/anaesthesia and management of benzodiazepine overdose
• Caution: Short duration of action (shorter than most benzodiazepines) — resedation can occur, requiring repeat dosing/monitoring; can precipitate withdrawal seizures in benzodiazepine-dependent patients

Related Concepts

1. 1Skeletal Muscle Relaxants

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