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Paper I — 2022 October (Supplementary) (2010 Scheme) — Q19

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Paper I
2022 October (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Depolarizing neuromuscular blocking agents

Q190.3 marksShort Answers

Answer

Succinylcholine (Suxamethonium) is the only clinically used depolarizing neuromuscular blocker — it binds nicotinic receptors at the motor end-plate and persistently depolarizes the membrane (unlike acetylcholine, it is not rapidly hydrolyzed by acetylcholinesterase), producing initial fasciculations followed by flaccid paralysis; used for rapid-sequence intubation because of its rapid onset and very short duration.

  1. 1Skeletal Muscle Relaxants

Other Years Asked

  1. 1(2023 January (Supplementary) (2019 Scheme)Short Essay · 8 marks
  2. 2Read the clinical problem and answer the following questions: 30 years old man was admitted in emergency ward with acute abdominal pain. After diagnosed with acute appendicitis, he was taken for surgery. On the operation table, after administration of a skeletal muscle relaxant, patient developed difficulty in breathing and went in for apnoea.2015 September (Supplementary) (2010 Scheme)Essay · 6 marks
  3. 3Read the clinical problem and answer the following questions: A 50 years old man was administered succinylcholine for endotracheal intubation. The patient developed prolonged muscle paralysis and apnea. (2+2+2)  What could be the cause of apnea in this patient  How will you treat the apnea  Name two muscle relaxants that you can use in this patient in future2021 May (Supplementary) (2010 Scheme)Essay · 6 marks
  4. 4Atracurium2020 February (Supplementary) (2010 Scheme)Short Note · 3 marks
  5. 5Mechanism of action of diazepam2014 March (2010 Scheme)Short Answer · 1 mark
  6. 6Mechanism of action of pancuronium.2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  7. 7Diazepam2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  8. 8Flumazenil2013 April (2010 Scheme)Short Answer · 1 mark
  9. 9Centrally acting muscle relaxants2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  10. 10Mechanism of action of diazepam.2016 February (2010 Scheme)Short Answer · 1 mark
  11. 11Mechanism of action of dantrolene sodium.2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  12. 12Dantrolene sodium in malignant hyperthermia2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  13. 13d-Tubocurarine2021 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
  14. 14Dantrolene in malignant hyperthermia.2025 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  15. 15Diazepam2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  16. 16Peripherally acting skeletal muscle relaxants2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  17. 17Uses of diazepam2017 February (2010 Scheme)Short Answer · 1 mark
  18. 18Competitive neuromuscular blockers2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  19. 19Dantrolene in malignant hyperthermia2019 February (2010 Scheme)Short Answer · 1 mark
  20. 20Centrally acting skeletal muscle relaxants2022 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  21. 21Skeletal muscle relaxants2022 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  22. 22Centrally acting skeletal muscle relaxants2024 March (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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