Paper I — 2022 May (Supplementary) (2010 Scheme) — Q19

Paper I

2022 May (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Centrally acting skeletal muscle relaxants

Q190.3 marksShort Answers★✓

Answer

Diazepam, Baclofen (also Tizanidine) — act supraspinally/spinally to reduce muscle tone and spasm frequency without paralyzing the neuromuscular junction; diazepam enhances GABAergic transmission, baclofen is a GABA-B agonist, tizanidine is a central alpha-2 agonist. Used in upper motor neurone spasticity (multiple sclerosis, spinal injury).

Related Concepts

1. 1Skeletal Muscle Relaxants

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