Paper I — 2025 August (Supplementary) (2010 Scheme) — Q9

Paper I

2025 August (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Dantrolene in malignant hyperthermia.

Q91 marksShort Answers★✓

Answer

Malignant hyperthermia results from uncontrolled Ca²⁺ release from the sarcoplasmic reticulum via the ryanodine receptor, causing sustained muscle contraction, hypermetabolism, and severe hyperthermia. Dantrolene directly blocks the ryanodine receptor, preventing further Ca²⁺ release and halting the sustained contraction and hypermetabolic state — making it the specific antidote for this condition.

Related Concepts

1. 1Skeletal Muscle Relaxants

Other Years Asked

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11. 11Mechanism of action of dantrolene sodium.2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
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