Paper I — 2016 October (Supplementary) (2010 Scheme) — Q9

Paper I

2016 October (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Mechanism of action of pancuronium.

Q91 marksShort Answers★✓

Answer

Pancuronium is a non-depolarizing (competitive) neuromuscular blocker. It competitively blocks nicotinic (N-M) acetylcholine receptors at the neuromuscular junction motor end-plate, preventing acetylcholine from binding and triggering depolarization — resulting in flaccid skeletal muscle paralysis without initial fasciculations. Its action can be reversed by anticholinesterases (e.g., neostigmine), which increase acetylcholine levels to competitively overcome the block.

Related Concepts

1. 1Skeletal Muscle Relaxants

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