Paper I — 2014 March (2010 Scheme) — Q10

Paper I

2014 March (2010 Scheme) · 40 marks · 120 min

Question

Mechanism of action of diazepam

Q101 marksShort Answers★✓

Answer

Diazepam binds to a specific benzodiazepine site on the GABA-A receptor complex and enhances GABA-mediated inhibitory neurotransmission by increasing the frequency of chloride channel opening in response to GABA. This increases chloride ion influx, hyperpolarizing the neuron and producing CNS depression (sedative, anxiolytic, anticonvulsant, and muscle relaxant effects).

Related Concepts

1. 1Skeletal Muscle Relaxants

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