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Paper II — 2022 May (Supplementary) (2010 Scheme) — Q8

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Paper II
2022 May (Supplementary) (2010 Scheme)

Question

Cilastatin with Imipenem

Q81 marksShort Answers

Answer

Imipenem is extensively metabolized and inactivated by the renal brush-border enzyme dehydropeptidase-I, which would otherwise destroy most of the dose before it could act, and generates a nephrotoxic metabolite. Cilastatin is a specific dehydropeptidase-I inhibitor with no antibacterial activity of its own — co-administering it blocks this renal breakdown, raising the effective urinary and plasma concentration of active imipenem and preventing the nephrotoxic metabolite from forming, making the combination both effective and safe for clinical use.

  1. 1Beta Lactam Antibiotics

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  3. 3(2024 June (Supplementary) (2019 Scheme)Short Essay · 8 marks
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  7. 7Classify cephalosporins. Mention the mechanism of action, adverse effects and uses of third generation cephalosporin. (2+2+2=6)2017 February (2010 Scheme)Essay · 6 marks
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  9. 9Mention Two drugs which can be given to treat enteric fever. Explain the mechanism of action, uses and adverse effects of any one. (2+4)2024 December (Supplementary) (2019 Scheme)Short Essay · 6 marks
  10. 104th generation cephalosporins2017 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  11. 11III generation cephalosporin2023 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  12. 12Second generation cephalosporins and its uses.2013 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  13. 13Penicillin2025 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  14. 14Beta-Lactamase inhibitors2021 May (Supplementary) (2010 Scheme)Short Note · 3 marks
  15. 15Specify the important spectrum of ciprofloxacin.2017 February (2010 Scheme)Short Answer · 1 mark
  16. 16Anti pseudomonal drugs2014 March (2010 Scheme)Short Answer · 1 mark
  17. 17Metronidazole and ceftriaxone for brain abscess2020 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
  18. 18Cotrimoxazole is NOT effective against infections caused by:2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
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  20. 20Combination of Amoxicillin and Clavulanic acid2025 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  21. 21Assertion (A): Vancomycin is used primarily to treat infections caused by Methicillin-resistant Staphylococcus aureus (MRSA). Reason (R): Vancomycin inhibits the formation of bacterial cell walls by binding to D-alanyl- D-alanine, a component of the peptidoglycan precursor.2025 March (Supplementary (SAY)) (2019 Scheme)MCQ (A/R) · 1 mark
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  23. 23Pharmacological basis for combining beta lactamase inhibitors with beta lactam antibiotics.2017 February (2010 Scheme)Short Answer · 1 mark
  24. 24The potent inhibitor of bacterial cell wall synthesis used for Neisseria gonorrhoeae infections is:2025 March (Supplementary (SAY)) (2019 Scheme)MCQ · 1 mark
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  26. 26Mention anti pseudomonal penicillins2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  27. 27Gram negative septicemia2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  28. 28Clavulanic acid with Amoxicillin2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
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