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Paper II — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qxx

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Paper II
2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Assertion (A): Vancomycin is used primarily to treat infections caused by Methicillin-resistant Staphylococcus aureus (MRSA). Reason (R): Vancomycin inhibits the formation of bacterial cell walls by binding to D-alanyl- D-alanine, a component of the peptidoglycan precursor.

Assertion) Vancomycin is used primarily to treat infections caused by Methicillin-resistant Staphylococcus aureus (MRSA). Reason) Vancomycin inhibits the formation of bacterial cell walls by binding to D-alanyl- D-alanine, a component of the peptidoglycan precursor.

  • a) Both A and R are true and R is the correct explanation of A
  • c) A is true but R is false
  • b) Both A and R are true and R is not the correct explanation of A
  • d) A is false but R is true
Qxx1 marksMCQs (A/R)

Answer

Correct answer: a) Both A and R are true and R is the correct explanation of A

Both statements are true, and R correctly explains A: vancomycin binds the D-alanyl-D-alanine terminus of the peptidoglycan precursor directly (rather than penicillin-binding proteins), blocking cell wall cross-linking through a mechanism independent of the altered PBP2a that makes MRSA resistant to beta-lactams — the specific reason vancomycin remains effective against MRSA where beta-lactams fail.

  1. 1Beta Lactam Antibiotics

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  3. 3(2024 June (Supplementary) (2019 Scheme)Short Essay · 8 marks
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  14. 14Beta-Lactamase inhibitors2021 May (Supplementary) (2010 Scheme)Short Note · 3 marks
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  27. 27Gram negative septicemia2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
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