Paper I — 2013 April (2010 Scheme) — Q7

Paper I

2013 April (2010 Scheme) · 40 marks · 180 min

Question

Nicorandil

Q73 marksShort Notes★✓

Answer

• Nicorandil is an antianginal drug with a dual mechanism:
  • Nitrate-like action: Releases nitric oxide → venodilatation → reduced preload
  • K⁺ATP channel opener: Opens ATP-sensitive potassium channels in vascular smooth muscle → arteriolar dilatation → reduced afterload
  • Also produces coronary vasodilatation, including of epicardial coronary arteries (useful in vasospastic angina)
• Uses: Prophylaxis and treatment of angina pectoris (stable and vasospastic)
• Adverse effects: Headache, flushing, oral and GI ulceration, hypotension
• Unlike conventional nitrates, tolerance develops less readily

Related Concepts

1. 1Antianginal Drugs

Other Years Asked

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2. 2(2022 July (Supplementary) (2019 Scheme)Essay · 9 marks
3. 3(2024 June (Supplementary) (2019 Scheme)Short Essay · 8 marks
4. 4Classify drugs used in the treatment of angina pectoris. What is the effect of nitrates on coronary blood flow. Describe the mechanism of action and any two adverse effects of nitrates. (2+1+2+1 =6)2017 February (2010 Scheme)Essay · 6 marks
5. 5A 60-year-old man gives history of chest pain, sweating and breathlessness on brisk walking, which is relieved on taking rest.  Classify drugs that are useful in this condition.  Explain the mechanism and pharmacological actions, uses and adverse effects of nitrates (2+4)2022 May (Supplementary) (2010 Scheme)Essay · 6 marks
6. 6Calcium channel blockers2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
7. 7Amlodipine2023 March (Supplementary) (2010 Scheme)Short Note · 3 marks
8. 8Two uses and two adverse effects of calcium channel blockers.2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
9. 9Use of morphine in left ventricular failure2017 February (2010 Scheme)Short Answer · 1 mark
10. 10Amlodipine and metoprolol in angina2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
11. 11Calcium channel blockers2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
12. 12Rationale of combining beta blockers with long acting nitrates2013 April (2010 Scheme)Short Answer · 1 mark
13. 13Morphine in Acute myocardial infarction2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
14. 14Glyceryl trinitrate.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
15. 15Rationale for use of calcium channel blockers in angina2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
16. 16Angina pectoris2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
17. 17Rationale for the use of nitrates in angina pectoris.2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
18. 18Nitrates in acute attack of angina.2016 February (2010 Scheme)Short Answer · 1 mark
19. 19Isosorbidedinitrate2021 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
20. 20Mechanism of action of nitrates.2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
21. 21Morphine in Acute left ventricular failure.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
22. 22Drugs for the prophylaxis of angina pectoris2014 March (2010 Scheme)Short Answer · 1 mark
23. 23Morphine in Acute left ventricular failure2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
24. 24Two uses and two adverse effect of nifedipine.2016 February (2010 Scheme)Short Answer · 1 mark
25. 25Sodium nitrite in the treatment of Cyanide poisoning2024 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
26. 26Beta blockers in angina2020 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
27. 27Anti anginal agents2024 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
28. 28Drugs used for PSVT2020 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks