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Paper II — 2023 July (Supplementary) (2019 Scheme) — Q11

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Paper II
2023 July (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Pharmacological basis for the use of Zidovudine in HIV.

Q114 marksShort Answers

Answer

Zidovudine is a nucleoside reverse transcriptase inhibitor. After intracellular phosphorylation to its active triphosphate form, it is incorporated into the growing proviral DNA chain by HIV reverse transcriptase and acts as a chain terminator (lacking the 3’-OH group needed for the next nucleotide), halting reverse transcription of the viral RNA genome into DNA — the essential first step HIV requires to integrate into the host genome. This mechanism is the pharmacological basis for its use as part of combination antiretroviral therapy, and for prevention of mother-to-child transmission, where blocking early viral replication in the exposed infant is critical.

  1. 1Antiviral Drugs

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  5. 5Protease inhibitors2019 February (2010 Scheme)Short Note · 3 marks
  6. 6Protease inhibitors in HIV infection.2017 February (2010 Scheme)Short Note · 3 marks
  7. 7Acyclovir2024 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  8. 8Oseltamivir2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  9. 9For herpes virus infection2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  10. 10Antiretroviral drugs2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  11. 11Mechanism of action of oseltamivir.2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  12. 12Non nucleoside reverse transcriptase inhibitors2016 February (2010 Scheme)Short Answer · 1 mark
  13. 13H1N1 viral infection.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  14. 14Mechanism of action of acyclovir2013 April (2010 Scheme)Short Answer · 1 mark
  15. 15Retro viral infections2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  16. 16Post exposure prophylaxis of HIV (acquired immunodeficiency syndrome)2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  17. 17Herpes zoster infection.2017 February (2010 Scheme)Short Answer · 1 mark
  18. 18Protease inhibitors2018 February (2010 Scheme)Short Answer · 1 mark
  19. 19HIV infection..2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  20. 20Non-nucleoside Reverse Transcriptase Inhibitors (nNRTIs)2020 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  21. 21Antiretroviral drugs2023 July (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  22. 22Protease inhibitors2025 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  23. 23Neuraminidase inhibitors2022 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  24. 24Anti-herpes virus drugs2021 December (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  25. 25Anti Hepatitis B viral drugs2021 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  26. 26Post-exposure prophylaxis in HIV infection2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  27. 27Anti-influenza virus drugs2025 August (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  28. 28Antiretroviral drugs.2023 January (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  29. 29Drugs for herpes simplex2022 February (2019 Scheme)Short Answer · 0.2 marks
  30. 30Drugs to treat Influenza.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  31. 31Neuraminidase inhibitors2024 March (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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