Paper II — 2013 April (2010 Scheme) — Q12

Paper II

2013 April (2010 Scheme) · 40 marks · 120 min

Question

Mechanism of action of acyclovir

Q121 marksShort Answers★✓

Answer

Acyclovir is a guanosine analogue antiviral. It is first phosphorylated to acyclovir monophosphate by the viral enzyme thymidine kinase (present only in virus-infected cells, giving selectivity), then converted to the triphosphate by host cell enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase and gets incorporated into the growing viral DNA chain, causing chain termination (it lacks the 3’-OH group needed for further chain elongation).

Related Concepts

1. 1Antiviral Drugs

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