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Paper II — 2023 January (Supplementary) (2019 Scheme) — Q12

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Paper II
2023 January (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Acyclovir

Q124 marksShort Answers

Answer

Acyclovir is a guanosine analogue, the prototype anti-herpes agent.

MOA: monophosphorylated by virus-encoded thymidine kinase (present in HSV/VZV-infected cells, not uninfected cells), then further phosphorylated by host kinases to the active triphosphate, which is incorporated into viral DNA as a chain terminator; viral DNA polymerase also binds it preferentially over host polymerase — a triple layer of selectivity.

Uses: herpes simplex virus infections (genital, orolabial, encephalitis), varicella-zoster virus infections (chickenpox, shingles) — most effective when started early.

Adverse effects: generally well tolerated; crystalline nephropathy with rapid IV infusion/inadequate hydration, GI upset, reversible neurotoxicity at high doses, particularly in renal impairment.

  1. 1Antiviral Drugs

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  5. 5Protease inhibitors2019 February (2010 Scheme)Short Note · 3 marks
  6. 6Protease inhibitors in HIV infection.2017 February (2010 Scheme)Short Note · 3 marks
  7. 7Acyclovir2024 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  8. 8Oseltamivir2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  9. 9For herpes virus infection2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  10. 10Antiretroviral drugs2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  11. 11Mechanism of action of oseltamivir.2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  12. 12Non nucleoside reverse transcriptase inhibitors2016 February (2010 Scheme)Short Answer · 1 mark
  13. 13H1N1 viral infection.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  14. 14Mechanism of action of acyclovir2013 April (2010 Scheme)Short Answer · 1 mark
  15. 15Retro viral infections2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  16. 16Post exposure prophylaxis of HIV (acquired immunodeficiency syndrome)2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  17. 17Herpes zoster infection.2017 February (2010 Scheme)Short Answer · 1 mark
  18. 18Protease inhibitors2018 February (2010 Scheme)Short Answer · 1 mark
  19. 19HIV infection..2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  20. 20Non-nucleoside Reverse Transcriptase Inhibitors (nNRTIs)2020 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  21. 21Antiretroviral drugs2023 July (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  22. 22Protease inhibitors2025 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  23. 23Neuraminidase inhibitors2022 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  24. 24Anti-herpes virus drugs2021 December (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  25. 25Anti Hepatitis B viral drugs2021 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  26. 26Post-exposure prophylaxis in HIV infection2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  27. 27Anti-influenza virus drugs2025 August (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  28. 28Antiretroviral drugs.2023 January (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  29. 29Drugs for herpes simplex2022 February (2019 Scheme)Short Answer · 0.2 marks
  30. 30Drugs to treat Influenza.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  31. 31Neuraminidase inhibitors2024 March (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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