Question
Therapeutic uses and adverse effects of rifampicin.
Q53 marksShort Notes
Answer
Therapeutic uses
- Tuberculosis (first-line drug, part of combination therapy)
- Leprosy (multibacillary and paucibacillary, part of MDT)
- Prophylaxis for close contacts of meningococcal meningitis and H. influenzae type B
- Carrier state elimination for meningococcus
Adverse effects
- Hepatotoxicity
- Orange-red discolouration of body secretions (urine, sweat, tears) — harmless but should be explained to patient
- Flu-like syndrome (with intermittent/interrupted dosing) — fever, chills, myalgia
- GI upset
- Potent hepatic microsomal enzyme induction — reduces efficacy of oral contraceptives, warfarin, corticosteroids, and other co-administered drugs
- Thrombocytopenia, haemolytic anaemia (rare, immunological)
- Cutaneous reactions, pruritus
- 1Antitubercular Drugs
Other Years Asked
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mild chest pain, weakness and fatigue for the last one month. In addition, he has developed low grade
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for which he took treatment from the hospital and became all right in 2 months. He stopped taking the
medicines after another 1 month, though he was told by the doctor to continue treatment. The sputum was
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- 2(2022 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
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diagnosis for primary pulmonary tuberculosis.
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Which drug is responsible for his complaints
What is the mechanism of its action in tuberculosis
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