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Paper II — 2025 March (Supplementary (SAY)) (2019 Scheme) — Q7

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Paper II
2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Describe the mechanism of action, adverse effects and uses of Rifampicin.

Q76 marksShort Essays

Answer

Rifampicin is a first-line antitubercular drug.

Mechanism of action: inhibits bacterial DNA-dependent RNA polymerase, blocking mRNA synthesis — bactericidal against both actively dividing and semi-dormant organisms, part of why it’s included in both the intensive and continuation phases of TB therapy.

Adverse effects: hepatotoxicity (additive with isoniazid’s own hepatotoxicity when combined), harmless orange-red discoloration of body fluids (urine, tears, sweat — important to pre-counsel patients about), and potent, broad-spectrum hepatic CYP450 induction — accelerating metabolism of oral contraceptives (contraceptive-failure risk), warfarin, and numerous other co-administered drugs.

Uses: tuberculosis (combination therapy, both treatment phases), leprosy (combination MDT), chemoprophylaxis for close contacts of meningococcal meningitis.

  1. 1Antitubercular Drugs

Other Years Asked

  1. 1A 45-year-old male factory worker weighing 60 kg reports to the hospital with cough and expectoration, mild chest pain, weakness and fatigue for the last one month. In addition, he has developed low grade fever for the last one week. He gives history of having suffered from tuberculosis of the lung one year back for which he took treatment from the hospital and became all right in 2 months. He stopped taking the medicines after another 1 month, though he was told by the doctor to continue treatment. The sputum was found to be positive for AFB and X-ray chest showed a 5 cm cavitary lesion in the right middle lobe and fibrotic changes in the upper lobe. He was diagnosed to be a previously treated and defaulted patient of pulmonary tuberculosis.2024 December (Supplementary) (2019 Scheme)Essay · 10 marks
  2. 2(2022 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
  3. 3A 45-year-old nurse complaining of evening rise of temperature since a month with loss of appetite and weight is presenting with sputum positive for AFB and diagnosis for primary pulmonary tuberculosis. (2023 March (Supplementary) (2010 Scheme)Essay · 6 marks
  4. 4Mr. Madhavan aged 40 yrs developed pulmonary tuberculosis and he was given treatment with first line anti-tubercular agents. After one month of regular treatment, he reported back with complaints of visual disturbances and difficulty in following traffic signals.  Which drug is responsible for his complaints  What is the mechanism of its action in tuberculosis  What is MDR-TB  How will you manage MDR-TB (1+2+1+2)2022 October (Supplementary) (2010 Scheme)Essay · 6 marks
  5. 5What is the pharmacological basis for the use of pyridoxine along with isoniazid.2025 March (Supplementary (SAY)) (2019 Scheme)Short Answer · 4 marks
  6. 6Treatment of Pulmonary tuberculosis2024 June (Supplementary) (2019 Scheme)Short Answer · 4 marks
  7. 7Rifampicin2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
  8. 8Isoniazid (INH)2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  9. 9Rifampicin.2014 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  10. 10Therapeutic uses and adverse effects of rifampicin.2013 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  11. 11Rifampicin.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  12. 12Pyridoxine should be given with Isoniazid.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  13. 13Treatment of multi drug resistant tuberculosis2016 February (2010 Scheme)Short Answer · 1 mark
  14. 14INH and pyridoxine2021 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
  15. 15Isoniazid hydrazide2019 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  16. 16Chemoprophylaxis in tuberculosis2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  17. 17Rifampicin2021 December (Supplementary) (2010 Scheme)Short Answer · 1 mark
  18. 18Brucellosis.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  19. 19Rifampicin2022 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
  20. 20Treatment of MDR-TB2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  21. 21Mechanism of action of INH2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  22. 22Multidrug therapy for tuberculosis2020 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
  23. 23First line anti tubercular drugs2014 March (2010 Scheme)Short Answer · 1 mark
  24. 24Streptomycin2021 December (Supplementary) (2010 Scheme)Short Answer · 1 mark
  25. 25Pyridoxine with isoniazid2021 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
  26. 26Mention four adverse effects of rifampicin2013 April (2010 Scheme)Short Answer · 1 mark
  27. 27Pyridoxine (Vitamin B6) with Isoniazid (INH) in Antitubercular therapy.2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark

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