Question
Pyridoxine (Vitamin B6) with Isoniazid (INH) in Antitubercular therapy.
Q8 1 marks Short Answers ★ ✓
Answer
Isoniazid interferes with pyridoxine (vitamin B6) metabolism — it structurally competes with pyridoxal phosphate-dependent enzyme reactions and increases pyridoxine’s renal excretion, producing a functional B6 deficiency that manifests as peripheral neuropathy. Co-administering pyridoxine replenishes this deficit and prevents the neuropathy, without reducing isoniazid’s own antitubercular effect — particularly important in patients at higher baseline neuropathy risk (malnourished patients, pregnancy, diabetics, alcoholics).
1 Antitubercular Drugs
Other Years Asked
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fever for the last one week. He gives history of having suffered from tuberculosis of the lung one year back
for which he took treatment from the hospital and became all right in 2 months. He stopped taking the
medicines after another 1 month, though he was told by the doctor to continue treatment. The sputum was
found to be positive for AFB and X-ray chest showed a 5 cm cavitary lesion in the right middle lobe and
fibrotic changes in the upper lobe. He was diagnosed to be a previously treated and defaulted patient of
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( 2023 March (Supplementary) (2010 Scheme) Essay · 6 marks 4 Mr. Madhavan aged 40 yrs developed pulmonary tuberculosis and he was given
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