Paper II — 2017 August (Supplementary) (2010 Scheme) — Q8

Paper II

2017 August (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Mechanism of action of INH

Q81 marksShort Answers★✓

Answer

Isoniazid (INH) is a prodrug, activated by the mycobacterial enzyme catalase-peroxidase (KatG). The activated form inhibits InhA (an enoyl-ACP reductase), blocking synthesis of mycolic acid, an essential component of the mycobacterial cell wall. This produces a bactericidal effect, particularly against rapidly dividing extracellular mycobacteria.

Related Concepts

1. 1Antitubercular Drugs

Other Years Asked

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2. 2(2022 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
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21. 21Treatment of MDR-TB2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
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