Paper I — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qii

Paper I

2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

The diuretic employed in refractory edema resistant to thiazide/loop diuretics is:

• a) Amiloride
• b) Acetazolamide
• c) Mannitol
• d) Spironolactone

Qii1 marksMCQs★✓

Answer

Correct answer: d) Spironolactone

Diuretic-resistant edema (e.g. in heart failure or cirrhosis) is frequently driven by secondary hyperaldosteronism. Adding spironolactone, an aldosterone antagonist acting at a different nephron site (collecting duct) than thiazides/loop diuretics, provides sequential nephron blockade and directly addresses the aldosterone-driven component of sodium retention that a loop or thiazide diuretic alone does not counter — restoring diuretic response in refractory edema.

Related Concepts

1. 1Drugs for Heart Failure

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