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Paper II — 2021 May (Supplementary) (2010 Scheme) — Q3

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Paper II
2021 May (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Lab diagnosis of malaria

Q35 marksShort Essays

Answer

Laboratory diagnosis of malaria (Plasmodium species):

  • Peripheral blood smear microscopy — gold standard; thick smear for screening, thin smear for species identification/parasitaemia quantification (Giemsa stain), ideally taken during/soon after a febrile episode.
  • Rapid diagnostic tests (RDTs) — HRP-2 (P. falciparum-specific) or pLDH/aldolase (pan-species) antigen detection.
  • QBC method — fluorescence-based concentration technique, more sensitive but does not allow precise species identification.
  • PCR — highly sensitive/specific, detects low-level/mixed infections.
  • Serology — detects past exposure, not useful for acute diagnosis.

Key species-identification features: P. falciparum — delicate ring forms, absence of larger stages in peripheral blood (sequestration), crescent-shaped gametocytes; P. vivax — amoeboid trophozoites, Schüffner’s dots; P. malariae — band-form trophozoites, “rosette” schizonts; P. ovale — oval, fimbriated RBCs.

  1. 1Malaria

Other Years Asked

  1. 1A 52 years old man presents with the complaints of intermittent high fever, rigors and headache for the past 6 days. He gives a history of fever on alternate days and on examination has hepatosplenomegaly. Answer the following.  What is the diagnosis of this condition  List the species of the causative agent  Name the definitive and intermediate hosts  Discuss the laboratory diagnosis of this condition  Enumerate the important preventive measures to prevent this disease (1+2+1+4+2)2019 July (Supplementary) (2010 Scheme)Essay · 10 marks
  2. 2E patient had hepatosplenomegaly, pallor++. A peripheral blood smear helped in the diagnosis.2013 September (Supplementary) (2010 Scheme)Essay · 10 marks
  3. 3A 45 years old male complaints of intermittent high grade fever which was cyclical and associated with rigor and chills. On examination he has hepatosplenomegaly. Answer the following:2014 September (Supplementary) (2010 Scheme)Essay · 10 marks
  4. 4An adult male presents with complaints of high grade fever with chills and rigor for the past 6 days. On examination, patient has anemia and hepatosplenomegaly. Peripheral smear examination shows multiple ring forms.2025 August (Supplementary) (2010 Scheme)Essay · 8 marks
  5. 5Pathogenesis and laboratory diagnosis of faciparum malariae.2013 April (2010 Scheme)Short Essay · 5 marks
  6. 6Laboratory diagnosis of falciparum malaria and its complications2018 July (Supplementary) (2010 Scheme)Short Essay · 5 marks
  7. 7Laboratory diagnosis of falciparum Malaria.2024 March (Supplementary) (2010 Scheme)Short Essay · 5 marks
  8. 8Asexual life cycle of plasmodium vivax.2019 February (2010 Scheme)Short Essay · 5 marks
  9. 9Laboratory diagnosis of malaria2021 February (Supplementary) (2010 Scheme)Short Essay · 5 marks
  10. 10Add a note on lab diagnosis of Pernicious Malaria.2022 February (2019 Scheme)Short Answer · 4 marks
  11. 11Describe the life cycle of plasmodium falciparum2025 March (Supplementary (SAY)) (2019 Scheme)Short Answer · 3 marks
  12. 12Name four complications of Falciparum malaria.2022 May (Supplementary) (2010 Scheme)Short Note · 2 marks
  13. 13Rapid diagnostic methods of Malaria2025 March (Supplementary) (2010 Scheme)Short Note · 2 marks
  14. 14Complications of falciparum malaria2023 July (Supplementary) (2010 Scheme)Short Note · 2 marks
  15. 15Name complications of falciparum malaria2021 December (Supplementary) (2010 Scheme)Short Note · 2 marks
  16. 16Life cycle of plasmodium falciparum.2016 February (2010 Scheme)Short Note · 2 marks
  17. 17Lab diagnosis of malaria2023 March (Supplementary) (2010 Scheme)Short Note · 2 marks
  18. 18Complication of falciparum malaria2024 August (Supplementary) (2010 Scheme)Short Note · 2 marks
  19. 19Complication of falciparum malaria2021 May (Supplementary) (2010 Scheme)Short Note · 2 marks
  20. 20Name two parasitic disease where man acts as intermediate host.2022 February (2019 Scheme)1 mark
  21. 21Name two rapid tests used for diagnosis of malaria.2022 July (Supplementary) (2019 Scheme)1 mark
  22. 22Name TWO complications of malignant malaria.2024 March (Supplementary) (2019 Scheme)1 mark
  23. 23A: Plasmodium falciparum is the species of Plasmodium producing most serious complications. R: Malaria is caused by bite of female Anopheles mosquito2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark

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