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Paper II — 2025 March (Supplementary) (2010 Scheme) — Q12

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Paper II
2025 March (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Rapid diagnostic methods of Malaria

Q122 marksShort Notes

Answer

Rapid diagnostic methods of malaria:

  • Rapid Diagnostic Tests (RDTs) — immunochromatographic tests detecting parasite antigens: histidine-rich protein-2 (HRP-2) (specific for P. falciparum) or lactate dehydrogenase (pLDH)/aldolase (pan-species); results within 15–20 minutes, useful in field settings without microscopy access.
  • QBC (Quantitative Buffy Coat) method — fluorescence-based concentration technique using acridine orange staining, more sensitive than routine smear but does not allow precise species identification; results available within minutes.
  • PCR — highly sensitive/specific for detecting low-level/mixed infections, though turnaround time is longer than RDTs/QBC and it is not truly a “rapid” bedside test.

Comparison with conventional method: peripheral blood smear microscopy remains the gold standard for definitive species identification and parasitaemia quantification, but RDTs and QBC offer faster results, particularly valuable in resource-limited or high-throughput field settings.

  1. 1Malaria

Other Years Asked

  1. 1A 52 years old man presents with the complaints of intermittent high fever, rigors and headache for the past 6 days. He gives a history of fever on alternate days and on examination has hepatosplenomegaly. Answer the following.  What is the diagnosis of this condition  List the species of the causative agent  Name the definitive and intermediate hosts  Discuss the laboratory diagnosis of this condition  Enumerate the important preventive measures to prevent this disease (1+2+1+4+2)2019 July (Supplementary) (2010 Scheme)Essay · 10 marks
  2. 2E patient had hepatosplenomegaly, pallor++. A peripheral blood smear helped in the diagnosis.2013 September (Supplementary) (2010 Scheme)Essay · 10 marks
  3. 3A 45 years old male complaints of intermittent high grade fever which was cyclical and associated with rigor and chills. On examination he has hepatosplenomegaly. Answer the following:2014 September (Supplementary) (2010 Scheme)Essay · 10 marks
  4. 4An adult male presents with complaints of high grade fever with chills and rigor for the past 6 days. On examination, patient has anemia and hepatosplenomegaly. Peripheral smear examination shows multiple ring forms.2025 August (Supplementary) (2010 Scheme)Essay · 8 marks
  5. 5Lab diagnosis of malaria2021 May (Supplementary) (2010 Scheme)Short Essay · 5 marks
  6. 6Pathogenesis and laboratory diagnosis of faciparum malariae.2013 April (2010 Scheme)Short Essay · 5 marks
  7. 7Laboratory diagnosis of falciparum malaria and its complications2018 July (Supplementary) (2010 Scheme)Short Essay · 5 marks
  8. 8Laboratory diagnosis of falciparum Malaria.2024 March (Supplementary) (2010 Scheme)Short Essay · 5 marks
  9. 9Asexual life cycle of plasmodium vivax.2019 February (2010 Scheme)Short Essay · 5 marks
  10. 10Laboratory diagnosis of malaria2021 February (Supplementary) (2010 Scheme)Short Essay · 5 marks
  11. 11Add a note on lab diagnosis of Pernicious Malaria.2022 February (2019 Scheme)Short Answer · 4 marks
  12. 12Describe the life cycle of plasmodium falciparum2025 March (Supplementary (SAY)) (2019 Scheme)Short Answer · 3 marks
  13. 13Name four complications of Falciparum malaria.2022 May (Supplementary) (2010 Scheme)Short Note · 2 marks
  14. 14Complications of falciparum malaria2023 July (Supplementary) (2010 Scheme)Short Note · 2 marks
  15. 15Name complications of falciparum malaria2021 December (Supplementary) (2010 Scheme)Short Note · 2 marks
  16. 16Life cycle of plasmodium falciparum.2016 February (2010 Scheme)Short Note · 2 marks
  17. 17Lab diagnosis of malaria2023 March (Supplementary) (2010 Scheme)Short Note · 2 marks
  18. 18Complication of falciparum malaria2024 August (Supplementary) (2010 Scheme)Short Note · 2 marks
  19. 19Complication of falciparum malaria2021 May (Supplementary) (2010 Scheme)Short Note · 2 marks
  20. 20Name two parasitic disease where man acts as intermediate host.2022 February (2019 Scheme)1 mark
  21. 21Name two rapid tests used for diagnosis of malaria.2022 July (Supplementary) (2019 Scheme)1 mark
  22. 22Name TWO complications of malignant malaria.2024 March (Supplementary) (2019 Scheme)1 mark
  23. 23A: Plasmodium falciparum is the species of Plasmodium producing most serious complications. R: Malaria is caused by bite of female Anopheles mosquito2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark

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