Paper II
2021 December (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Name complications of falciparum malaria

Q82 marksShort Notes

Answer

Complications of falciparum malaria (driven largely by cytoadherence/sequestration of parasitized RBCs via PfEMP1):

  1. Cerebral malaria — altered consciousness, seizures, coma.
  2. Severe anaemia — from haemolysis and marrow suppression.
  3. Acute kidney injury — including “blackwater fever” (massive intravascular haemolysis with haemoglobinuria).
  4. Hypoglycaemia — from parasite glucose consumption and impaired hepatic gluconeogenesis.
  5. Pulmonary complications — acute respiratory distress syndrome (ARDS).
  6. Placental malaria — in pregnancy, low birth weight, severe maternal disease.
  7. Disseminated Intravascular Coagulation (DIC) and circulatory collapse/shock.

(All complications are more common with P. falciparum than other species, due to its ability to infect RBCs of all ages and its unique cytoadherence property.)

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