Question
Complications of falciparum malaria
Q122 marksShort Notes
Answer
Complications of falciparum malaria (driven largely by cytoadherence/sequestration of parasitized RBCs via PfEMP1):
- Cerebral malaria — altered consciousness, seizures, coma.
- Severe anaemia — from haemolysis and marrow suppression.
- Acute kidney injury — including “blackwater fever” (massive intravascular haemolysis with haemoglobinuria).
- Hypoglycaemia — from parasite glucose consumption and impaired hepatic gluconeogenesis.
- Pulmonary complications — acute respiratory distress syndrome (ARDS).
- Placental malaria — in pregnancy, low birth weight, severe maternal disease.
- Disseminated Intravascular Coagulation (DIC) and circulatory collapse/shock.
- 1Malaria
Other Years Asked
- 1A 52 years old man presents with the complaints of intermittent high fever, rigors and
headache for the past 6 days. He gives a history of fever on alternate days and on
examination has hepatosplenomegaly. Answer the following.
What is the diagnosis of this condition
List the species of the causative agent
Name the definitive and intermediate hosts
Discuss the laboratory diagnosis of this condition
Enumerate the important preventive measures to prevent this disease
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- 2E patient had
hepatosplenomegaly, pallor++. A peripheral blood smear helped in the diagnosis.2013 September (Supplementary) (2010 Scheme)Essay · 10 marks
- 3A 45 years old male complaints of intermittent high grade fever which was cyclical and
associated with rigor and chills. On examination he has hepatosplenomegaly. Answer
the following:2014 September (Supplementary) (2010 Scheme)Essay · 10 marks
- 4An adult male presents with complaints of high grade fever with chills and rigor for the
past 6 days. On examination, patient has anemia and hepatosplenomegaly.
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- 20Name two parasitic disease where man acts as intermediate host.2022 February (2019 Scheme)1 mark
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- 22Name TWO complications of malignant malaria.2024 March (Supplementary) (2019 Scheme)1 mark
- 23A: Plasmodium falciparum is the species of Plasmodium producing most serious complications.
R: Malaria is caused by bite of female Anopheles mosquito2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
