Paper II — 2013 September (Supplementary) (2010 Scheme) — Q7

Paper II

2013 September (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Ivermectin.

Q73 marksShort Notes★✓

Answer

Ivermectin is a broad-spectrum anthelmintic/antiparasitic drug.

Mechanism of action

• Binds selectively to glutamate-gated chloride channels in invertebrate nerve and muscle cells
• Causes increased chloride ion influx, hyperpolarization, and flaccid paralysis of the parasite

Uses

• Onchocerciasis (river blindness) — drug of choice
• Strongyloidiasis
• Scabies and lice (topical/oral)
• Lymphatic filariasis (as part of mass drug administration, with albendazole/DEC)

Adverse effects

• Mazzotti reaction (fever, pruritus, lymphadenopathy — due to death of microfilariae) in onchocerciasis treatment
• Dizziness, nausea
• Generally well tolerated; safety in pregnancy not established

Related Concepts

1. 1Anthelmintic Drugs

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1. 1Albendazole2024 June (Supplementary) (2019 Scheme)Short Answer · 4 marks
2. 2Albendazole.2023 January (Supplementary) (2019 Scheme)Short Answer · 4 marks
3. 3Ivermectin2022 February (2019 Scheme)Short Answer · 4 marks
4. 4Albendazole2023 March (Supplementary) (2010 Scheme)Short Note · 3 marks
5. 5Albendazole2018 February (2010 Scheme)Short Note · 3 marks
6. 6Ivermectin2021 February (Supplementary) (2010 Scheme)Short Note · 3 marks
7. 7Albendazole2024 March (Supplementary) (2010 Scheme)Short Note · 3 marks
8. 8Filariasis.2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
9. 9Diethylcarbamazine citrate (DEC)2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
10. 10Treatment of ascariasis2015 February (2010 Scheme)Short Answer · 1 mark
11. 11Round worm infestation2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
12. 12Treatment of onchocercosis2016 February (2010 Scheme)Short Answer · 1 mark
13. 13Hookworm infestation2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
14. 14In treatment of filariasis2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
15. 15Mebendazole2020 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
16. 16Treatment of hook worm infestation2018 February (2010 Scheme)Short Answer · 1 mark
17. 17Albendazole2022 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
18. 18Ivermectin2022 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
19. 19Diethylcarbamazine citrate2021 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
20. 20Ivermectin2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
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22. 22Drugs used for treatment of Filariasis2024 March (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
23. 23Drugs to treat Filariasis.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
24. 24Drugs for treating Filariasis.2023 January (Supplementary) (2019 Scheme)Short Answer · 0.2 marks