Paper II — 2023 January (Supplementary) (2019 Scheme) — Q9

Paper II

2023 January (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Albendazole.

Q94 marksShort Answers★✓

Answer

Albendazole is a broad-spectrum benzimidazole anthelmintic.

MOA: binds parasitic beta-tubulin, inhibiting microtubule polymerization — the parasite cannot maintain its cytoskeleton, transport glucose across its gut lining, or divide, leading to energy depletion and death.

Uses: soil-transmitted helminthiasis (ascariasis, hookworm, whipworm), neurocysticercosis, hydatid disease, strongyloidiasis.

Adverse effects: GI upset, hepatotoxicity with prolonged/high-dose use, teratogenicity (avoided in pregnancy), bone marrow suppression with prolonged high-dose therapy.

Related Concepts

1. 1Anthelmintic Drugs

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