Paper II — 2022 February (2019 Scheme) — Q11

Paper II

2022 February (2019 Scheme) · 100 marks · 180 min

Question

Ivermectin

Q114 marksShort Answers★✓

Answer

Ivermectin is a broad-spectrum antiparasitic. MOA: binds glutamate-gated chloride channels found in invertebrate (nematode/arthropod) nerve and muscle cells but absent in mammals — opening these channels causes hyperpolarization, paralysis, and death of the parasite, giving genuine selective toxicity. Uses: strongyloidiasis, onchocerciasis (river blindness), lymphatic filariasis (mass drug administration programs), scabies, and cutaneous larva migrans. Adverse effects: generally well tolerated; Mazzotti-like reaction (fever, pruritus, lymphadenopathy from dying microfilariae) particularly in onchocerciasis treatment, dizziness, GI upset.

Related Concepts

1. 1Anthelmintic Drugs

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