Paper II — 2021 February (Supplementary) (2010 Scheme) — Q4

Paper II

2021 February (Supplementary) (2010 Scheme)

Question

Ivermectin

Q43 marksShort Notes★✓

Answer

Ivermectin is a broad-spectrum anthelmintic/antiparasitic drug.

Mechanism of action

• Binds to glutamate-gated chloride channels in invertebrate nerve/muscle cells, causing increased chloride influx, hyperpolarization, and flaccid paralysis of the parasite

Uses

• Onchocerciasis (drug of choice)
• Strongyloidiasis
• Scabies and lice
• Lymphatic filariasis (mass drug administration)

Adverse effects

• Mazzotti reaction in onchocerciasis treatment (fever, pruritus, lymphadenopathy)
• Dizziness, nausea
• Generally well tolerated

Related Concepts

1. 1Anthelmintic Drugs

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