Paper II — 2023 March (Supplementary) (2010 Scheme) — Q4

Paper II

2023 March (Supplementary) (2010 Scheme)

Question

Albendazole

Q43 marksShort Notes★✓

Answer

Albendazole is a broad-spectrum benzimidazole anthelmintic.

MOA: albendazole → binds parasitic beta-tubulin → inhibits microtubule polymerization → the parasite cannot maintain its cytoskeleton, transport glucose across its gut lining, or divide → energy depletion and death over days. Selectivity relies on higher affinity for parasitic than mammalian beta-tubulin.

Uses: soil-transmitted helminthiasis (ascariasis, hookworm, whipworm), neurocysticercosis, hydatid disease, strongyloidiasis.

Adverse effects: GI upset, hepatotoxicity with prolonged/high-dose use, teratogenicity (avoided in pregnancy), bone marrow suppression with prolonged high-dose therapy (as in hydatid disease treatment).

Related Concepts

1. 1Anthelmintic Drugs

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