Paper II — 2024 December (Supplementary) (2019 Scheme) — Qxviii
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Paper II
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min
Question
Assertion (A): Ticarcillin is combined with Gentamicin for Pseudomonas infection, especially in
neutropenic patients.
Reason (R): Ticarcillin inhibits cell wall synthesis and Gentamicin inhibits protein synthesis and both of
them are bactericidal.
a) Both A and R are true, and R is the correct explanation of A
c) A is true, but R is false
b) Both A and R are true, and R is not the correct explanation of A
d) A is false, but R is true
Qxviii1 marksMCQs
Answer
Correct answer: a) Both A and R are true, and R is the correct explanation of A
Both statements are true, and R correctly explains A: ticarcillin’s cell-wall-weakening action improves gentamicin’s access to its intracellular ribosomal target, producing a synergistic bactericidal effect greater than either drug alone — the classic rationale for this combination in severe Pseudomonas infections, particularly in neutropenic patients where reliable bactericidal killing is critical given impaired host immune clearance.
