Paper I
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Mention four prostaglandin analogs and their respective clinical indications.

Q134 marksShort Answers

Answer

  • Dinoprostone (PGE2) — cervical ripening and labour induction.
  • Misoprostol (PGE1 analogue) — labour induction/medical termination of pregnancy (with mifepristone); also gastric mucosal protection with NSAID use.
  • Carboprost (PGF2-alpha analogue) — postpartum hemorrhage unresponsive to oxytocin.
  • Latanoprost (PGF2-alpha analogue) — lowers intraocular pressure in open-angle glaucoma by increasing uveoscleral outflow.
  • Alprostadil (PGE1) — maintains ductal patency in neonates with ductus-dependent congenital heart disease; also used for erectile dysfunction.

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