Question
Propylthiouracil / Carbimazole for treatment of Thyroid storm
Q14 0.3 marks Short Answers ★ ✓
Answer
Propylthiouracil is the appropriate choice — beyond thioamides’ shared thyroid peroxidase-inhibiting mechanism, PTU has a second, distinct action: it also inhibits peripheral deiodinase, blocking conversion of T4 to the more active T3 in peripheral tissues. This additional peripheral action gives PTU a faster additional benefit in severely thyrotoxic states, the specific reason PTU (not carbimazole/methimazole) is preferred for thyroid storm.
1 Thyroid Hormones and Antithyroid Drugs
Other Years Asked
1 T4 and very low TSH
levels. A diagnosis of hyperthyroidism was made.
( 2022 July (Supplementary) (2019 Scheme) Essay · 10 marks 2 Compare Radioactive Iodine and Carbimazole. 2024 March (Supplementary) (2019 Scheme) Short Essay · 8 marks 3 Classify Thyroid inhibitor drugs. Describe the mechanism of action, and adverse
effects of carbimazole. Explain the role of iodides in hyperthyroidism. (2+2+2) 2022 May (Supplementary) (2010 Scheme) Essay · 6 marks 4 ( 2023 July (Supplementary) (2019 Scheme) Essay · 6 marks 5 A 32years old woman, presented with complaints of weight loss, palpitations,
sweating, irregular menses and occasional tremors of hands since 2-3 months.
Clinical examination revealed a diffusely enlarged thyroid gland and blood tests
showed decreased TSH. She was started on medication for Grave’s disease. 2025 March (Supplementary) (2010 Scheme) Essay · 6 marks 6 Classify antithyroid drugs. Write the advantages and disadvantages of using
radioactive Iodine. (2+2+2) 2021 February (Supplementary) (2010 Scheme) Essay · 6 marks 7 A 35 years old woman came with complaints of heat intolerance, retraction of upper eyelid
and menstrual irregularities. Her T3 , T4 , FT4 & FT3 are elevated while TSH is suppressed.
Answer the following: 2015 February (2010 Scheme) Essay · 6 marks 8 Treatment of thyrotoxic crisis. 2023 January (Supplementary) (2019 Scheme) Short Answer · 4 marks 9 Pharmacotherapy of Thyrotoxic crisis (thyroid storm) 2024 June (Supplementary) (2019 Scheme) Short Answer · 4 marks 10 Mechanism of action, uses and adverse effects of Radio active iodine. 2025 March (Supplementary (SAY)) (2019 Scheme) Short Answer · 4 marks 11 Carbimazole 2022 October (Supplementary) (2010 Scheme) Short Note · 3 marks 12 Radioactive Iodine 2024 March (Supplementary) (2010 Scheme) Short Note · 3 marks 13 Anti thyroid drugs 2014 September (Supplementary) (2010 Scheme) Short Note · 3 marks 14 Radioactive Iodine 2021 May (Supplementary) (2010 Scheme) Short Note · 3 marks 15 Lugol’s Iodine is given for 10 days prior to thyroidectomy surgery for Grave’s
disease. 2023 July (Supplementary) (2010 Scheme) Short Answer · 1 mark 16 Anti-thyroid drugs 2018 July (Supplementary) (2010 Scheme) Short Answer · 1 mark 17 Explain the use of propranolol in thyrotoxicosis. 2018 February (2010 Scheme) Short Answer · 1 mark 18 Methimazole acts by: 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 19 Antithyroid drugs 2013 April (2010 Scheme) Short Answer · 1 mark 20 Drug used in thyrotoxic crisis 2014 March (2010 Scheme) Short Answer · 1 mark 21 Propylthiouracil 2025 August (Supplementary) (2010 Scheme) Short Answer · 1 mark 22 Anti- thyroid drugs safe during pregnancy 2017 August (Supplementary) (2010 Scheme) Short Answer · 1 mark 23 Thyrotoxic crisis. 2015 September (Supplementary) (2010 Scheme) Short Answer · 1 mark 24 Anti thyroid drugs 2016 October (Supplementary) (2010 Scheme) Short Answer · 1 mark 25 Radioactive iodine 2020 February (Supplementary) (2010 Scheme) Short Answer · 1 mark 26 Use of Propranolol in Thyrotoxic crisis. 2024 March (Supplementary) (2010 Scheme) Short Answer · 1 mark 27 The preferred drug for her is: 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 28 Antithyroid drugs 2019 February (2010 Scheme) Short Answer · 0.3 marks 
