Question
Lugol’s Iodine is given for 10 days prior to thyroidectomy surgery for Grave’s
disease.
Q9 1 marks Short Answers ★ ✓
Answer
High-dose Lugol’s iodine paradoxically inhibits thyroid hormone release and synthesis — the Wolff-Chaikoff effect — a rapid-onset (hours to days) but transient autoregulatory suppression, reducing both thyroid hormone output and, importantly, gland vascularity and friability. Given for about 10 days before thyroidectomy, this reduces intraoperative bleeding risk and makes the gland easier and safer to operate on. It is not used as sole or long-term therapy, since the thyroid typically “escapes” the Wolff-Chaikoff effect within 1-2 weeks and resumes normal hormone handling.
1 Thyroid Hormones and Antithyroid Drugs
Other Years Asked
1 T4 and very low TSH
levels. A diagnosis of hyperthyroidism was made.
( 2022 July (Supplementary) (2019 Scheme) Essay · 10 marks 2 Compare Radioactive Iodine and Carbimazole. 2024 March (Supplementary) (2019 Scheme) Short Essay · 8 marks 3 Classify Thyroid inhibitor drugs. Describe the mechanism of action, and adverse
effects of carbimazole. Explain the role of iodides in hyperthyroidism. (2+2+2) 2022 May (Supplementary) (2010 Scheme) Essay · 6 marks 4 ( 2023 July (Supplementary) (2019 Scheme) Essay · 6 marks 5 A 32years old woman, presented with complaints of weight loss, palpitations,
sweating, irregular menses and occasional tremors of hands since 2-3 months.
Clinical examination revealed a diffusely enlarged thyroid gland and blood tests
showed decreased TSH. She was started on medication for Grave’s disease. 2025 March (Supplementary) (2010 Scheme) Essay · 6 marks 6 Classify antithyroid drugs. Write the advantages and disadvantages of using
radioactive Iodine. (2+2+2) 2021 February (Supplementary) (2010 Scheme) Essay · 6 marks 7 A 35 years old woman came with complaints of heat intolerance, retraction of upper eyelid
and menstrual irregularities. Her T3 , T4 , FT4 & FT3 are elevated while TSH is suppressed.
Answer the following: 2015 February (2010 Scheme) Essay · 6 marks 8 Treatment of thyrotoxic crisis. 2023 January (Supplementary) (2019 Scheme) Short Answer · 4 marks 9 Pharmacotherapy of Thyrotoxic crisis (thyroid storm) 2024 June (Supplementary) (2019 Scheme) Short Answer · 4 marks 10 Mechanism of action, uses and adverse effects of Radio active iodine. 2025 March (Supplementary (SAY)) (2019 Scheme) Short Answer · 4 marks 11 Carbimazole 2022 October (Supplementary) (2010 Scheme) Short Note · 3 marks 12 Radioactive Iodine 2024 March (Supplementary) (2010 Scheme) Short Note · 3 marks 13 Anti thyroid drugs 2014 September (Supplementary) (2010 Scheme) Short Note · 3 marks 14 Radioactive Iodine 2021 May (Supplementary) (2010 Scheme) Short Note · 3 marks 15 Anti-thyroid drugs 2018 July (Supplementary) (2010 Scheme) Short Answer · 1 mark 16 Explain the use of propranolol in thyrotoxicosis. 2018 February (2010 Scheme) Short Answer · 1 mark 17 Methimazole acts by: 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 18 Antithyroid drugs 2013 April (2010 Scheme) Short Answer · 1 mark 19 Drug used in thyrotoxic crisis 2014 March (2010 Scheme) Short Answer · 1 mark 20 Propylthiouracil 2025 August (Supplementary) (2010 Scheme) Short Answer · 1 mark 21 Anti- thyroid drugs safe during pregnancy 2017 August (Supplementary) (2010 Scheme) Short Answer · 1 mark 22 Thyrotoxic crisis. 2015 September (Supplementary) (2010 Scheme) Short Answer · 1 mark 23 Anti thyroid drugs 2016 October (Supplementary) (2010 Scheme) Short Answer · 1 mark 24 Radioactive iodine 2020 February (Supplementary) (2010 Scheme) Short Answer · 1 mark 25 Use of Propranolol in Thyrotoxic crisis. 2024 March (Supplementary) (2010 Scheme) Short Answer · 1 mark 26 The preferred drug for her is: 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 27 Carbimazole for treatment of Thyroid storm 2024 August (Supplementary) (2010 Scheme) Short Answer · 0.3 marks 28 Antithyroid drugs 2019 February (2010 Scheme) Short Answer · 0.3 marks 
