Paper II — 2024 June (Supplementary) (2019 Scheme) — Q14

Paper II

2024 June (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Cyclosporine / Sirolimus for graft rejection reaction in Renal failure patient. Name the following (Two examples for each): (8x1=8)

Q140.2 marksShort Answers★✓

Answer

Sirolimus is the appropriate choice in a patient with renal failure — unlike calcineurin inhibitors, mTOR inhibition does not share calcineurin’s renal vasoconstrictive nephrotoxic mechanism, making sirolimus a specific alternative where calcineurin-inhibitor nephrotoxicity would be a particular concern. Cyclosporine’s dose-limiting nephrotoxicity (direct renal vasoconstriction and, with chronic use, interstitial fibrosis) makes it a poor choice in a patient whose renal function is already compromised.

Related Concepts

1. 1Immunosuppressants

Other Years Asked

1. 1(2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
2. 2Ramu, a 35 years old male is suffering from end stage kidney disease. His brother has come forward to donate his kidney for Ramu. What immunosuppressant drugs are required to inhibit rejection of transplanted kidney. Explain the mechanism of action and side effects of cyclosporine. (2+2+2)2018 July (Supplementary) (2010 Scheme)Essay · 6 marks
3. 3Monoclonal antibodies and their uses2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
4. 4Cyclosporine2016 February (2010 Scheme)Short Note · 3 marks
5. 5Cyclosporine2021 December (Supplementary) (2010 Scheme)Short Note · 3 marks
6. 6Tacrolimus2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
7. 7Assertion (A): Cyclosporine is used as a part of induction regimen to prevent organ transplant rejection. Reason (R): Cyclosporine inhibits TNFα secreted by activated macrophages and other immune cells.2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
8. 8Immunosuppressive in organ transplantation2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
9. 9Calcineurin inhibitors2014 March (2010 Scheme)Short Answer · 1 mark
10. 10Immunosuppressants2021 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
11. 11Drugs for prevention of rejection of organ transplantation2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
12. 12Cytokine inhibitors.2022 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
13. 13Drugs to treat Irritable bowel disease2024 March (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
14. 14Calcineurin inhibitors2024 March (Supplementary) (2019 Scheme)Short Answer · 0.2 marks