Question
Monoclonal antibodies and their uses
Q9 4 marks Short Answers ★ ✓
Answer
Monoclonal antibodies are laboratory-produced antibodies engineered to bind a single, specific target antigen with high selectivity.
Infliximab, Adalimumab (anti-TNF-alpha) — rheumatoid arthritis, inflammatory bowel disease, psoriasis.Rituximab (anti-CD20) — non-Hodgkin lymphoma, rheumatoid arthritis (B-cell depletion).Trastuzumab (anti-HER2) — HER2-positive breast cancer.Bevacizumab (anti-VEGF) — colorectal and other cancers, blocking tumour angiogenesis.Omalizumab (anti-IgE) — severe allergic asthma.Palivizumab (anti-RSV) — prophylaxis against respiratory syncytial virus in high-risk infants.
Their high target specificity generally gives a more favorable adverse-effect profile than conventional cytotoxic/broad-immunosuppressive agents, though infusion reactions and increased infection risk (from targeted immune pathway suppression) remain class-wide concerns.
1 Immunosuppressants
Other Years Asked
1 ( 2023 July (Supplementary) (2019 Scheme) Short Essay · 8 marks 2 Ramu, a 35 years old male is suffering from end stage kidney disease. His brother
has come forward to donate his kidney for Ramu. What immunosuppressant drugs
are required to inhibit rejection of transplanted kidney. Explain the mechanism of
action and side effects of cyclosporine. (2+2+2) 2018 July (Supplementary) (2010 Scheme) Essay · 6 marks 3 Cyclosporine 2016 February (2010 Scheme) Short Note · 3 marks 4 Cyclosporine 2021 December (Supplementary) (2010 Scheme) Short Note · 3 marks 5 Tacrolimus 2019 July (Supplementary) (2010 Scheme) Short Note · 3 marks 6 Assertion (A): Cyclosporine is used as a part of induction regimen to prevent organ transplant rejection.
Reason (R): Cyclosporine inhibits TNFα secreted by activated macrophages and other immune cells. 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 7 Immunosuppressive in organ transplantation 2014 September (Supplementary) (2010 Scheme) Short Answer · 1 mark 8 Calcineurin inhibitors 2014 March (2010 Scheme) Short Answer · 1 mark 9 Immunosuppressants 2021 February (Supplementary) (2010 Scheme) Short Answer · 0.3 marks 10 Drugs for prevention of rejection of organ transplantation 2022 October (Supplementary) (2010 Scheme) Short Answer · 0.3 marks 11 Cytokine inhibitors. 2022 July (Supplementary) (2019 Scheme) Short Answer · 0.2 marks 12 Sirolimus for graft rejection reaction in Renal failure patient.
Name the following (Two examples for each): (8x1=8) 2024 June (Supplementary) (2019 Scheme) Short Answer · 0.2 marks 13 Drugs to treat Irritable bowel disease 2024 March (Supplementary) (2019 Scheme) Short Answer · 0.2 marks 14 Calcineurin inhibitors 2024 March (Supplementary) (2019 Scheme) Short Answer · 0.2 marks 
