Paper II — 2024 December (Supplementary) (2019 Scheme) — Qxx

Paper II

2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Assertion (A): Cyclosporine is used as a part of induction regimen to prevent organ transplant rejection. Reason (R): Cyclosporine inhibits TNFα secreted by activated macrophages and other immune cells.

• a) Both A and R are true, and R is the correct explanation of A
• c) A is true, but R is false
• b) Both A and R are true, and R is not the correct explanation of A
• d) A is false, but R is true (PTO)

Qxx1 marksMCQs★✓

Answer

Correct answer: c) A is true, but R is false

A is true — cyclosporine is indeed used as part of induction/maintenance immunosuppressive regimens to prevent organ transplant rejection. R is false: cyclosporine does not inhibit TNF-alpha (that is the mechanism of biologic agents such as infliximab/etanercept) — it binds the immunophilin cyclophilin, and the resulting complex inhibits calcineurin, blocking NFAT-mediated IL-2 gene transcription and thereby T-cell activation.

Related Concepts

1. 1Immunosuppressants

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8. 8Calcineurin inhibitors2014 March (2010 Scheme)Short Answer · 1 mark
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