Question
Calcineurin inhibitors
Q20 0.2 marks Short Answers ★ ✓
Answer
Cyclosporine, Tacrolimus — bind intracellular immunophilins (cyclophilin and FKBP respectively), and the resulting complex inhibits calcineurin, blocking NFAT-mediated IL-2 transcription; used to prevent organ transplant rejection.
1 Immunosuppressants
Other Years Asked
1 ( 2023 July (Supplementary) (2019 Scheme) Short Essay · 8 marks 2 Ramu, a 35 years old male is suffering from end stage kidney disease. His brother
has come forward to donate his kidney for Ramu. What immunosuppressant drugs
are required to inhibit rejection of transplanted kidney. Explain the mechanism of
action and side effects of cyclosporine. (2+2+2) 2018 July (Supplementary) (2010 Scheme) Essay · 6 marks 3 Monoclonal antibodies and their uses 2022 July (Supplementary) (2019 Scheme) Short Answer · 4 marks 4 Cyclosporine 2016 February (2010 Scheme) Short Note · 3 marks 5 Cyclosporine 2021 December (Supplementary) (2010 Scheme) Short Note · 3 marks 6 Tacrolimus 2019 July (Supplementary) (2010 Scheme) Short Note · 3 marks 7 Assertion (A): Cyclosporine is used as a part of induction regimen to prevent organ transplant rejection.
Reason (R): Cyclosporine inhibits TNFα secreted by activated macrophages and other immune cells. 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 8 Immunosuppressive in organ transplantation 2014 September (Supplementary) (2010 Scheme) Short Answer · 1 mark 9 Calcineurin inhibitors 2014 March (2010 Scheme) Short Answer · 1 mark 10 Immunosuppressants 2021 February (Supplementary) (2010 Scheme) Short Answer · 0.3 marks 11 Drugs for prevention of rejection of organ transplantation 2022 October (Supplementary) (2010 Scheme) Short Answer · 0.3 marks 12 Cytokine inhibitors. 2022 July (Supplementary) (2019 Scheme) Short Answer · 0.2 marks 13 Sirolimus for graft rejection reaction in Renal failure patient.
Name the following (Two examples for each): (8x1=8) 2024 June (Supplementary) (2019 Scheme) Short Answer · 0.2 marks 14 Drugs to treat Irritable bowel disease 2024 March (Supplementary) (2019 Scheme) Short Answer · 0.2 marks 
