Question
Mention four groups of antiasthmatic drugs giving two examples each. How will you treat a
case of acute severe exacerbation of bronchial asthma. (4+2)
Q96 marksShort Essays
Answer
Four groups of antiasthmatic drugs, two examples each
| Group | Examples |
|---|
| Beta-2 agonists | Salbutamol, Salmeterol |
| Inhaled corticosteroids | Budesonide, Fluticasone |
| Leukotriene pathway modifiers | Montelukast, Zafirlukast |
| Anticholinergics | Ipratropium, Tiotropium |
Treatment of acute severe exacerbation of bronchial asthma
- High-flow oxygen to maintain SpO2, with continuous monitoring
- Nebulized short-acting beta-2 agonist (Salbutamol), repeated/continuous as needed
- Nebulized ipratropium bromide added for additional bronchodilation
- Systemic corticosteroids (IV/oral) — started early, given their onset takes hours, to reduce airway inflammation and prevent relapse
- IV magnesium sulfate in severe, poorly responsive cases (additional bronchodilator effect)
- Assisted ventilation if the patient develops respiratory fatigue/failure despite the above
- 1Respiratory System
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