Paper I
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Mention four groups of antiasthmatic drugs giving two examples each. How will you treat a case of acute severe exacerbation of bronchial asthma. (4+2)

Q96 marksShort Essays

Answer

Four groups of antiasthmatic drugs, two examples each

GroupExamples
Beta-2 agonistsSalbutamol, Salmeterol
Inhaled corticosteroidsBudesonide, Fluticasone
Leukotriene pathway modifiersMontelukast, Zafirlukast
AnticholinergicsIpratropium, Tiotropium

Treatment of acute severe exacerbation of bronchial asthma

  • High-flow oxygen to maintain SpO2, with continuous monitoring
  • Nebulized short-acting beta-2 agonist (Salbutamol), repeated/continuous as needed
  • Nebulized ipratropium bromide added for additional bronchodilation
  • Systemic corticosteroids (IV/oral) — started early, given their onset takes hours, to reduce airway inflammation and prevent relapse
  • IV magnesium sulfate in severe, poorly responsive cases (additional bronchodilator effect)
  • Assisted ventilation if the patient develops respiratory fatigue/failure despite the above

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