Paper I — 2023 March (Supplementary) (2010 Scheme) — Q6

Paper I

2023 March (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Salbutamol

Q63 marksShort Notes★✓

Answer

Salbutamol is a short-acting beta-2 selective adrenergic agonist.

MOA: salbutamol → beta-2 receptor stimulation → ↑adenylyl cyclase activity → ↑cAMP → bronchial smooth muscle relaxation.

Uses: acute bronchial asthma attack (inhaled, rapid relief), prevention of exercise-induced bronchospasm, acute exacerbation of COPD, and (off-label) as a tocolytic to delay preterm labour.

Adverse effects: fine skeletal muscle tremor (beta-2 receptors in skeletal muscle), tachycardia and palpitations (some beta-1 cross-reactivity at higher/systemic doses), hypokalemia (beta-2-mediated intracellular K⁺ shift), nervousness.

Related Concepts

1. 1Respiratory System

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