Paper I — 2024 December (Supplementary) (2019 Scheme) — Qxvi

Paper I

2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Assertion (A): Nitroglycerine is administered by sublingual route in acute attack of angina pectoris. Reason (R): Nitroglycerine has high oral bioavailability

• a) Both A and R are true, and R is the correct explanation of A
• b) Both A and R are true, and R is not the correct explanation of A
• c) A is true, but R is false
• d) A is false, but R is true

Qxvi1 marksMCQs★✓

Answer

Correct answer: c) A is true, but R is false

A is true — nitroglycerine is given sublingually for acute anginal attacks, for rapid onset. R is false: nitroglycerine actually has very low oral bioavailability, due to extensive first-pass hepatic metabolism — this is precisely why the sublingual route is used, to bypass first-pass metabolism entirely, not because oral bioavailability is high.

Related Concepts

1. 1Introduction and Routes of Drug Administration

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