Paper I — 2022 May (Supplementary) (2010 Scheme) — Q9

Paper I

2022 May (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Sublingual administration of drugs

Q91 marksShort Answers★✓

Answer

The sublingual mucosa is thin and richly vascularized, allowing rapid drug absorption directly into the systemic (superior vena cava) circulation, bypassing hepatic first-pass metabolism entirely. This makes the route ideal for drugs with high first-pass metabolism or those needing a rapid onset of action — e.g. glyceryl trinitrate for acute anginal attacks, where onset within 1–2 minutes is clinically essential and oral bioavailability would otherwise be destroyed by first-pass hepatic metabolism.

Related Concepts

1. 1Introduction and Routes of Drug Administration

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