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Paper II — 2022 October (Supplementary) (2010 Scheme) — Q10

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Paper II
2022 October (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Give two examples of antifungal drugs.

Q102 marksShort Notes

Answer

Two examples of antifungal drugs:

  1. Amphotericin B (a polyene) — binds ergosterol in the fungal cell membrane, creating pores causing leakage of cell contents; broad-spectrum, used for severe/systemic mycoses.
  2. Fluconazole (an azole) — inhibits fungal cytochrome P450-dependent lanosterol 14-alpha-demethylase, blocking ergosterol synthesis; widely used for candidiasis and cryptococcal meningitis maintenance therapy.

(Other valid examples: itraconazole, voriconazole; caspofungin (echinocandin); terbinafine (allylamine); griseofulvin.)

  1. 1General Mycology

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