Question
Non systemic antacids
Q43 marksShort Notes
Answer
Non-systemic antacids are poorly absorbed alkaline compounds that neutralize gastric acid locally without producing significant systemic alkalosis.
Examples
- Aluminium hydroxide
- Magnesium hydroxide/trisilicate
- Calcium carbonate (mostly non-systemic, minimal absorption)
Advantages over systemic antacids (e.g., sodium bicarbonate)
- Do not cause systemic (metabolic) alkalosis
- Do not cause significant sodium load — safer in hypertension/cardiac failure
- Longer duration of acid-neutralizing action
Adverse effects
- Aluminium hydroxide: constipation, phosphate depletion
- Magnesium hydroxide: diarrhoea
- (Often combined to offset each other’s bowel effects)
- Can interfere with absorption of other drugs (e.g., tetracyclines, fluoroquinolones) via chelation
- 1Quinolones
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