Paper II — 2024 March (Supplementary) (2019 Scheme) — Q11

Paper II

2024 March (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Ciprofloxacin

Q114 marksShort Answers★✓

Answer

Ciprofloxacin is a second-generation fluoroquinolone.

MOA: inhibits bacterial DNA gyrase (primary target in Gram-negatives) and topoisomerase IV, preventing DNA unwinding/religation during replication — bactericidal.

Uses: urinary tract infections, typhoid fever, gastroenteritis, respiratory and skin/soft tissue infections, anthrax post-exposure prophylaxis.

Adverse effects: tendinopathy/tendon rupture, cartilage damage in developing joints (avoided in children/pregnancy), QT prolongation, lowered seizure threshold, photosensitivity.

Related Concepts

1. 1Quinolones

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