Paper I — 2020 February (Supplementary) (2010 Scheme) — Q13

Paper I

2020 February (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Give two examples of live attenuated vaccines.

Q132 marksShort Notes★✓

Answer

Two examples of live attenuated vaccines (vaccines containing a weakened form of the live pathogen, which replicates in the host without causing full-blown disease, generating a robust and durable immune response, often after a single dose):

1. BCG (Bacille Calmette-Guérin) vaccine — a live attenuated strain of Mycobacterium bovis, protecting particularly against severe childhood forms of tuberculosis.
2. Oral polio vaccine (OPV) — contains live attenuated poliovirus strains, given orally, inducing both systemic and local intestinal (mucosal IgA) immunity.

(Other valid examples: MMR vaccine — measles, mumps, rubella; varicella vaccine; yellow fever vaccine; oral typhoid vaccine, Ty21a.)

Related Concepts

1. 1Vaccines and Immunoprophylaxis

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