Paper II
2025 March (Supplementary) (2010 Scheme)

Question

Azole antifungals

Q200.3 marksShort Answers

Answer

Fluconazole, Itraconazole (also Voriconazole) — inhibit fungal cytochrome P450 14-alpha-demethylase, blocking ergosterol synthesis and disrupting fungal membrane integrity; used for candidiasis, cryptococcal meningitis, and dermatophyte/dimorphic fungal infections.

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