Paper II — 2024 March (Supplementary) (2010 Scheme) — Q4

Paper II

2024 March (Supplementary) (2010 Scheme)

Question

Anti Helicobacter Pylori Drugs

Q43 marksShort Notes★✓

Answer

H. pylori eradication requires combination therapy to reduce the resistance-emergence risk monotherapy would carry against this organism.

Standard triple therapy: a proton pump inhibitor + two antibiotics (typically Clarithromycin and Amoxicillin, or Metronidazole in penicillin-allergic patients), given for 10-14 days — the PPI creates a less hostile environment for the antibiotics to work while directly promoting ulcer healing.

Bismuth-based quadruple therapy: Bismuth subsalicylate, Metronidazole, Tetracycline, plus a PPI — used where clarithromycin resistance is prevalent or triple therapy has failed; bismuth itself has direct antibacterial action against H. pylori plus a mucosal-coating protective effect.

Rationale: dual antibiotic coverage specifically reduces resistance-emergence risk that monotherapy would carry against a single bacterial species, the same combination-therapy logic applied throughout antimicrobial therapy.

Related Concepts

1. 1Peptic Ulcer Disease and Gastro oesophageal Reflux Disease

Other Years Asked

1. 1(2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
2. 2Enumerate the drugs used in treatment of Peptic ulcer. Briefly describe any one group. Write one Helicobacter pylori eradication regimen. (6+2)2024 March (Supplementary) (2019 Scheme)Short Essay · 8 marks
3. 3(2022 February (2019 Scheme)Short Essay · 8 marks
4. 4(2023 July (Supplementary) (2010 Scheme)Essay · 6 marks
5. 5Classify drugs used in treatment of Peptic ulcer. Describe briefly Omeprazole. (3+3)2024 August (Supplementary) (2010 Scheme)Essay · 6 marks
6. 6Enumerate two drug groups used to treat peptic ulcer with two examples each. Write the mechanism of action of both groups. Write one H.pylori eradication regimen (2+2+2)2024 December (Supplementary) (2019 Scheme)Short Essay · 6 marks
7. 7Read the case history and answer the following questions. Mr. Raman 32 years has developed severe epigastric pain after taking tab. Ibuprofen 400mg tds for his joint pain2014 September (Supplementary) (2010 Scheme)Essay · 6 marks
8. 8(2023 January (Supplementary) (2019 Scheme)Short Essay · 5 marks
9. 9Pharmacotherapy of Inflammatory Bowel Disease2022 February (2019 Scheme)Short Answer · 4 marks
10. 10Proton pump inhibitors2015 February (2010 Scheme)Short Note · 3 marks
11. 11Proton pump inhibitors2014 March (2010 Scheme)Short Note · 3 marks
12. 12Proton pump inhibitors2021 December (Supplementary) (2010 Scheme)Short Note · 3 marks
13. 13H2 blockers2021 May (Supplementary) (2010 Scheme)Short Note · 3 marks
14. 14Peptic ulcer protective agents2018 July (Supplementary) (2010 Scheme)Short Note · 3 marks
15. 15Proton pump inhibitors.2017 February (2010 Scheme)Short Note · 3 marks
16. 16Omeprazole2020 February (Supplementary) (2010 Scheme)Short Note · 3 marks
17. 17Omeprazole2025 August (Supplementary) (2010 Scheme)Short Note · 3 marks
18. 18Rabeprazole.2015 September (Supplementary) (2010 Scheme)Short Note · 3 marks
19. 19Lansoprazole2022 October (Supplementary) (2010 Scheme)Short Note · 3 marks
20. 20Pantoprazole.2025 March (Supplementary) (2010 Scheme)Short Note · 3 marks
21. 21Sucralfate in gastric ulcer2019 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
22. 22Comment on the interaction between itraconazole and omeprazole.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
23. 23GERD.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
24. 24Esomeprazole2021 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
25. 25Omeprazole is used in peptic ulcer – State reason2013 April (2010 Scheme)Short Answer · 1 mark
26. 26Which of the following classes of drugs is most commonly used as the first-line pharmacologic treatment for GERD2025 March (Supplementary (SAY)) (2019 Scheme)MCQ (Case) · 1 mark
27. 27Proton pump inhibitors2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
28. 28Peptic ulcer2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
29. 29H2 blockers2014 March (2010 Scheme)Short Answer · 1 mark
30. 30Triple drug regimen in helicobacter pylori infection2018 February (2010 Scheme)Short Answer · 1 mark
31. 31H.Pylori infection2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
32. 32Lansoprazole, amoxicillin and clarithromycin in H. pylori infection2019 February (2010 Scheme)Short Answer · 1 mark
33. 33Proton pump inhibitors2019 February (2010 Scheme)Short Answer · 0.3 marks
34. 34cimetidine is used in Peptic Ulcer Disease (PUD) Name the following (Two examples for each) (5x1=5)2023 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
35. 35Non systemic antacids.2022 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks